منابع مشابه
Mads at the nuclear pore
In This Issue In This Issue Build actin at the right place, right time ells explore their environment by sending out filopodia and lamellipodia. These protrusions encounter extra-cellular matrix components that encourage adhesion and cell spreading through actin polymerization. On page 881, DeMali et al. show how sites of cell adhesion specifically attract actin-polymerizing proteins, thus link...
متن کاملTranscriptional regulation at the nuclear pore complex.
The nonrandom spatial distribution of chromosomes and genes in the eukaryotic nucleus has been appreciated for decades, although a detailed understanding of the functional role of such positioning has remained illusive. The most prominent structural feature of the nucleus is the nuclear periphery, classically considered as a zone of gene repression caused by the presence of heterochromatin and ...
متن کاملNo waiting at the nuclear pore complex
Airport security checkpoints might take a lesson from the nuclear pore complex (NPC), where, according to Dange et al., there are no long lines and no slowdown despite the hubbub around them. The group used single-molecule video microscopy, with a localization precision of about the width of a protein, to track single molecules of labeled, cargo-carrying receptors entering the NPC in vivo. They...
متن کاملThe nuclear pore complex
M OLECULAR trafficking between the nucleus and the cytoplasm of interphase eukaryotic cells occurs via the nuclear pore complexes (NPCs), 1 organelles with a roughly cylindrical shape (~,120 um in diameter and ~70-um high) that are embedded in the double-membraned nuclear envelope (NE). The NPC allows passive diffusion of ions and small molecules through an aqueous channel with a physical diame...
متن کاملThe nuclear pore complex.
Over the past years, significant progress has been made both in the analysis of the structural and molecular organization of the nuclear pore complex (NPC) and the mechanism of nuclear transport. In this minireview, I will focus on some of the recent developments in this field. Structural studies employing high resolution EM have revealed a detailed view of the three-dimensional organization of...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1595iti2